ASIC3
Acid-sensing ion channel 3 (ASIC3) also known as amiloride-sensitive cation channel 3 (ACCN3) or testis sodium channel 1 (TNaC1) is a protein that in humans is encoded by the ASIC3 gene. The ASIC3 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels (ASICs) in mammals.[5] The cDNA of this gene was first cloned in 1998.[6][7] The ASIC genes have splicing variants that encode different proteins that are called isoforms.
These genes are mainly expressed in the central and peripheral nervous system.
ASICs can form both homotrimeric (meaning composed of three identical subunits) and heterotrimeric channels.[8]
Structure and function
[edit]This gene encodes a member of the ASIC/ENaC superfamily of proteins.[9] The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane (TM) regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The TM regions are generally symbolized as TM1 (clone to N-terminus) and TM2 (close to C-terminus).
The pore of the channel through which ions selectively flow from the extracellular side into the cytoplasm is formed by the three TM2 regions of the trimer.[5]
Interactions
[edit]ASIC3 has been shown to interact with LIN7B,[10] GOPC[10], MAGI1[10], and Ugr 9-1[11].
References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000213199 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038276 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b Hanukoglu I (February 2017). "ASIC and ENaC type sodium channels: conformational states and the structures of the ion selectivity filters". The FEBS Journal. 284 (4): 525–545. doi:10.1111/febs.13840. PMID 27580245. S2CID 24402104.
- ^ Ishibashi K, Marumo F (April 1998). "Molecular cloning of a DEG/ENaC sodium channel cDNA from human testis". Biochemical and Biophysical Research Communications. 245 (2): 589–593. Bibcode:1998BBRC..245..589I. doi:10.1006/bbrc.1998.8483. PMID 9571199.
- ^ de Weille JR, Bassilana F, Lazdunski M, Waldmann R (August 1998). "Identification, functional expression and chromosomal localisation of a sustained human proton-gated cation channel". FEBS Letters. 433 (3): 257–260. Bibcode:1998FEBSL.433..257D. doi:10.1016/S0014-5793(98)00916-8. PMID 9744806. S2CID 24431941.
- ^ Babinski K, Catarsi S, Biagini G, Séguéla P (September 2000). "Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+". The Journal of Biological Chemistry. 275 (37): 28519–28525. doi:10.1074/jbc.M004114200. hdl:11380/304669. PMID 10842183.
- ^ Hanukoglu I, Hanukoglu A (April 2016). "Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases". Gene. 579 (2): 95–132. doi:10.1016/j.gene.2015.12.061. PMC 4756657. PMID 26772908.
- ^ a b c Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ (November 2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current". The Journal of Biological Chemistry. 279 (45): 46962–46968. doi:10.1074/jbc.M405874200. PMID 15317815.
- ^ Andreev YA, Osmakov DI, Koshelev SG, Maleeva EE, Logashina YA, Palikov VA, et al. (December 2018). "Analgesic Activity of Acid-Sensing Ion Channel 3 (ASIС3) Inhibitors: Sea Anemones Peptides Ugr9-1 and APETx2 versus Low Molecular Weight Compounds". Marine Drugs. 16 (12): 500. doi:10.3390/md16120500. PMC 6316600. PMID 30545037.
Further reading
[edit]- Babinski K, Lê KT, Séguéla P (January 1999). "Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties". Journal of Neurochemistry. 72 (1): 51–57. doi:10.1046/j.1471-4159.1999.0720051.x. PMID 9886053. S2CID 10506798.
- Catarsi S, Babinski K, Séguéla P (October 2001). "Selective modulation of heteromeric ASIC proton-gated channels by neuropeptide FF". Neuropharmacology. 41 (5): 592–600. doi:10.1016/S0028-3908(01)00107-1. PMID 11587714. S2CID 568441.
- Alvarez de la Rosa D, Zhang P, Shao D, White F, Canessa CM (February 2002). "Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous system". Proceedings of the National Academy of Sciences of the United States of America. 99 (4): 2326–2331. Bibcode:2002PNAS...99.2326A. doi:10.1073/pnas.042688199. PMC 122364. PMID 11842212.
- Anzai N, Deval E, Schaefer L, Friend V, Lazdunski M, Lingueglia E (May 2002). "The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons". The Journal of Biological Chemistry. 277 (19): 16655–16661. doi:10.1074/jbc.M201087200. PMID 11872753.
- Chen CC, Zimmer A, Sun WH, Hall J, Brownstein MJ, Zimmer A (June 2002). "A role for ASIC3 in the modulation of high-intensity pain stimuli". Proceedings of the National Academy of Sciences of the United States of America. 99 (13): 8992–8997. Bibcode:2002PNAS...99.8992C. doi:10.1073/pnas.122245999. PMC 124411. PMID 12060708.
- Leonard AS, Yermolaieva O, Hruska-Hageman A, Askwith CC, Price MP, Wemmie JA, et al. (February 2003). "cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1". Proceedings of the National Academy of Sciences of the United States of America. 100 (4): 2029–2034. Bibcode:2003PNAS..100.2029L. doi:10.1073/pnas.252782799. PMC 149953. PMID 12578970.
- Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ (November 2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current". The Journal of Biological Chemistry. 279 (45): 46962–46968. doi:10.1074/jbc.M405874200. PMID 15317815.
- Price MP, Thompson RJ, Eshcol JO, Wemmie JA, Benson CJ (December 2004). "Stomatin modulates gating of acid-sensing ion channels". The Journal of Biological Chemistry. 279 (51): 53886–53891. doi:10.1074/jbc.M407708200. PMID 15471860.
- Jones NG, Slater R, Cadiou H, McNaughton P, McMahon SB (December 2004). "Acid-induced pain and its modulation in humans". The Journal of Neuroscience. 24 (48): 10974–10979. doi:10.1523/JNEUROSCI.2619-04.2004. PMC 6730214. PMID 15574747.
- Su X, Li Q, Shrestha K, Cormet-Boyaka E, Chen L, Smith PR, et al. (December 2006). "Interregulation of proton-gated Na(+) channel 3 and cystic fibrosis transmembrane conductance regulator". The Journal of Biological Chemistry. 281 (48): 36960–36968. doi:10.1074/jbc.M608002200. PMID 17012229.
External links
[edit]- Human ASIC3 genome location and ASIC3 gene details page in the UCSC Genome Browser.
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