Entry - 191950 - URTICARIA, FAMILIAL LOCALIZED HEAT - OMIM - (OMIM.ORG)

 
ICD+
191950

URTICARIA, FAMILIAL LOCALIZED HEAT


Clinical Synopsis
 

Skin
- Delayed heat urticaria at contact area
Inheritance
- Autosomal dominant
▲ Close

▼ TEXT

Michaelsson and Ros (1971) described a delayed heat urticaria, limited to the area of contact, in a 48-year-old female, 2 of her 3 children, 1 of her 2 sisters, and 4 of the latter's 5 children. Repeated heat exposure showed a decrease in response. Local pretreatment with lidocaine completely inhibited whealing. Oral antihistamines lessened the urticarial response. A higher percentage of basophils were degranulated in vitro in the experimental subject than in the controls. Acetylcholine as an allergen was postulated.


▼ REFERENCES

  1. Michaelsson, G., Ros, A.-M. Familial localized heat urticaria of delayed type. Acta Derm. Venerol. 51: 279-283, 1971. [PubMed: 4105776, related citations]


Creation Date:
Victor A. McKusick : 6/2/1986
Edit History:
mimadm : 6/7/1995
supermim : 3/16/1992
supermim : 3/20/1990
ddp : 10/27/1989
marie : 3/25/1988
reenie : 6/2/1986

191950

URTICARIA, FAMILIAL LOCALIZED HEAT


MONDO: 0008634;  



TEXT

Michaelsson and Ros (1971) described a delayed heat urticaria, limited to the area of contact, in a 48-year-old female, 2 of her 3 children, 1 of her 2 sisters, and 4 of the latter's 5 children. Repeated heat exposure showed a decrease in response. Local pretreatment with lidocaine completely inhibited whealing. Oral antihistamines lessened the urticarial response. A higher percentage of basophils were degranulated in vitro in the experimental subject than in the controls. Acetylcholine as an allergen was postulated.


REFERENCES

  1. Michaelsson, G., Ros, A.-M. Familial localized heat urticaria of delayed type. Acta Derm. Venerol. 51: 279-283, 1971. [PubMed: 4105776]


Creation Date:
Victor A. McKusick : 6/2/1986

Edit History:
mimadm : 6/7/1995
supermim : 3/16/1992
supermim : 3/20/1990
ddp : 10/27/1989
marie : 3/25/1988
reenie : 6/2/1986



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2025 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2025 Johns Hopkins University.
Printed: Dec. 9, 2025