Hi J,
I know this topic maybe a little widely and more about business depends of views than really focusing to c# or ASP, but i think it will be interesting and benefit us to have some ideas about how scaling and comparing Pro/Con to design solutions to our own projects (forcus on web) we want build.
Here is some small topic i think of:

• Monolithic
• Microservice
• (N) Layers
  ...
  And i been thinking this topic maybe better if it more about talk show with guest than in depth coding like the vid you did about APIs tour with Shayne Boyer (the vid i like most in series btw <3)
  Last but not least, thanks for provide amazing content Jeff :)