Sex Chromosome Specialization and Degeneration in Mammals
@article{Graves2006SexCS,
title={Sex Chromosome Specialization and Degeneration in Mammals},
author={Jennifer Ann Marshall Graves},
journal={Cell},
year={2006},
volume={124},
pages={901-914},
url={https://api.semanticscholar.org/CorpusID:8379688}
}568 Citations
Gene content evolution on the X chromosome.
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Sequence and structural diversity of mouse Y chromosomes
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The results support the hypothesis that the mouse sex chromosomes are engaged in ongoing intragenomic conflict and reduction in sex-linked diversity is incompatible with neutral demographic processes alone, but is consistent with recent positive selection on genes active during spermatogenesis.
Sex Chromosomes Evolution in Mammals
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The latest findings have revealed that mam‑ malian sex chromosomes evolved from a pair of autosome 166 million years ago and in two groups of rodents the mole vole and the Japanese spiny rat the Y chromosome has been removed completely and a new sex determination system has evolved.
Y Chromosome Evolution
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The acquisition of testis-expressed genes and their amplifications on the Y chromosome are discussed and the molecular studies of the Y chromosomal structures reveal some unexpected similarities in different evolutionary lineages.
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Origin of Amniote Sex Chromosomes: An Ancestral Super-Sex Chromosome, or Common Requirements?
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Comparative gene mapping and whole genome sequencing have now turned up other surprising relationships; different regions of the amniote genome that have become sex determining in some taxa seem to share synteny, or share sequence, in others.
Y-chromosome evolution: emerging insights into processes of Y-chromosome degeneration
- 2013
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Comparison of young and old Y chromosomes has given further insights into the evolutionary and molecular forces triggering Y-chromosome degeneration and into the Darwinian destiny of the Y chromosome.
Mammalian Sex Chromosome Evolution
- 2013
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Findings of evolutionary ‘strata’ on the sex chromosome of mammals suggest that multiple events have given rise to the current arrangement of genes on the X and Y chromosomes of mammals, and new studies utilising more divergent genomic data are challenging conclusions regarding the number and frequency of events.
Extinction of chromosomes due to specialization is a universal occurrence
- 2020
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The evolution of mammalian orthologs is examined to determine if the selective forces that led to the degeneration of the Y chromosome are unique in the genome, and the results of the study suggest these forces are not exclusive to the Y chromosomes.
82 References
Gene dosage in the evolution and function of mammalian sex chromosomes
- 1998
Biology
Evidence is reviewed that heteromorphic sex chromosomes evolved from an autosomal pair, and that one of the consequences of X–Y differentiation is the evolution of dosage compensation by X inactivation and upregulation of the active X, which in turn has selected for a highly conserved X chromosome.
The human Y chromosome, in the light of evolution
- 2001
Biology
Far from being random and diverse, known human Y-chromosome genes show just a few distinct expression profiles, and their relative functional conformity reflects evolutionary factors inherent to sex-specific chromosomes.
Steps in the evolution of heteromorphic sex chromosomes
- 2005
Biology
Evidence that recombination suppression occurs progressively in evolutionarily independent cases is reviewed, suggesting that selection drives loss of recombination over increasingly large regions.
Evolution of the mammalian Y chromosome and sex-determining genes.
- 1998
Biology
It is suggested here that, rather than acting as a transcriptional activator, the SRY gene acts to inhibit its paralogue SOX3, which in turn inhibits an ancient autosomal sex-determining gene SOX9.
Sex and the genome
- 2004
Biology
A new study in mice adds a missing piece of the puzzle: the composition of the X chromosome in mammals is influenced by inactivation of the sex chromosomes during male meiosis.
The rise and fall of SRY.
- 2002
Biology
Comparisons between species reveal when and how SRY, the testis-determining gene, evolved, and how it is dispensable, having been lost at least twice independently in different rodent lineages.
The origin and function of the mammalian Y chromosome and Y‐borne genes – an evolving understanding
- 1995
Biology
The addition–attrition hypothesis predicts that the pseudoautosomal region of the human X is merely the last relic of the latest addition, and evolved functions in male sex determination and differentiation distinct from the general functions of their X‐linked partners.
The degeneration of Y chromosomes.
- 2000
Biology
The results suggest that the effective population sizes of evolving Y or neo-Y chromosomes are severely reduced, as expected if some or all of the hypothesized processes leading to degeneration are operative.





