Overview of studies of treatments for hand eczema—the EDEN hand eczema survey

@article{Coevorden2004OverviewOS,
  title={Overview of studies of treatments for hand eczema—the EDEN hand eczema survey},
  author={A. M. van Coevorden and P. J. Coenraads and {\AA}. Svensson and J. N. Bouwes Bavinck and Thomas L. Diepgen and Luigi Naldi and Peter Elsner and H. C. Williams},
  journal={British Journal of Dermatology},
  year={2004},
  volume={151},
  url={https://api.semanticscholar.org/CorpusID:35402103}
}
A large number of interventions ranging from topical steroids to oral ciclosporin are used, but their evidence base and the best methods to assess their efficacy are uncertain.
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85 Citations
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85 Citations

Evidence-Based Management of Hand Eczema

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Hand eczema.

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Topical Treatment of Hand Eczema: Corticosteroids

There is a clear need for good-quality randomized controlled trials on existing and new treatment options for hand eczema, which can increase the risk of adverse effects.

Successful retreatment with alitretinoin in patients with relapsed chronic hand eczema

Patients with severe chronic hand eczema (CHE) often respond to therapy with oral alitretinoin (9‐cis retinoic acid), however, the efficacy of alitRetinoin after disease relapse has not been demonstrated.

Update on the use of alitretinoin in treating chronic hand eczema

Several large-scale clinical studies have demonstrated oral alitretinoin’s high efficacy rate, its safe tolerability profile, and its positive impact on quality of life, validating it as a therapeutic option for patients with severe chronic hand eczema refractory to standard treatment.

Update on the use of alitretinoin in treating chronic hand eczema

Several large-scale clinical studies have demonstrated oral alitretinoin’s high efficacy rate, its safe tolerability profile, and its positive impact on quality of life, validating it as a therapeutic option for patients with severe chronic hand eczema refractory to standard treatment.

Treatment of severe, chronic hand eczema: results from a UK‐wide survey

The results indicated that the treatment approaches favoured by UK dermatologists differ, and Psoralen combined with ultraviolet A (PUVA) and alitretinoin were identified as the most frequent first‐line treatment options for hyperkeratotic HE, whereas oral corticosteroids were identified for vesicular HE.

Management of chronic hand eczema

It is concluded that despite the abundance of topical and systemic treatment options, disease management in patients with severe chronic HE is frequently inadequate and there is a strong need for RCTs of existing and new treatment options based on clearly diagnosed subtypes of HE and its severity.

Alitretinoin (Toctino): new oral retinoid for chronic hand eczema

Alitretinoin (Toctino) is a new oral retinoid to treat severe chronic hand eczema that has failed to respond to topical steroids. In this New products review Dr John English discusses the clinical…

Interventions for hand eczema.

Irradiation with ultraviolet (UV) light: local combination ultraviolet light therapy (PUVA) may lead to improvement in investigator-rated symptom control when compared to local narrow-band UVB after 12 weeks of treatment (RR 0.76, 95% CI 0.82 to 6.06), including application site burning/pruritus.
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14 References

Long‐term, intermittent treatment of chronic hand eczema with mometasone furoate

It is concluded that long‐term, intermittent treatment of chronic hand eczema with mometasone furoate fatty cream is effective and safe.

Comparison of cyclosporine and topical betamethasone-17,21-dipropionate in the treatment of severe chronic hand eczema.

Low-dose cyclosporine at 3 mg/kg/day is as effective as topical BDP in the treatment of chronic hand Eczema and could be useful as an alternative treatment for severe chronic hand eczema in patients unresponsive to conventional treatment.

Treatment of hyperkeratotic dermatitis of the palms (eczema keratoticum) with oral acitretin. A single-blind placebo-controlled study.

It is concluded that 30 mg of acitretin is efficacious and safe to use in patients with hyperkeratotic dermatitis of the palms, and after 4 weeks of treatment, a 51% reduction of all symptoms was observed among patients receiving ac itretin.

Hand eczema in Swedish adults - changes in prevalence between 1983 and 1996.

The study indicates that the prevalence of hand eczema in Swedish adults had decreased between 1983 and 1996 despite an increasing prevalence of childhood Eczema, and a decreased occupational exposure to skin irritants is a probable cause.

Evaluating the outcome of treatment. Shouldn't We be asking patients if they are better?

Systematic reviews in health care: Assessing the quality of controlled clinical trials.

The concept of study quality and the methods used to assess quality are discussed and the methodology for both the assessment of quality and its incorporation into systematic reviews and meta-analysis is discussed.

Quality of reporting of randomized trials as a measure of methodologic quality.

Similar quality of reporting may hide important differences in methodologic quality, and well-conducted trials may be reported badly, so a clear distinction should be made between these 2 dimensions of the quality of RCTs.

Improving the quality of reporting of randomized controlled trials. The CONSORT statement.

The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials

The revised CONSORT statement is intended to improve the reporting of an RCT, enabling readers to understand a trial's conduct and to assess the validity of its results.