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242 Citations
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Viral Tracers for the Analysis of Neural Circuits
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This chapter discusses how the pseudorabies virus (PRV) strain Bartha, an attenuated form of a pig alphaherpesvirus, is an excellent retrograde transneuronal tracer for labeling neural networks in central nervous system networks involving chains of two or more functionally connected neurons.
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An overview of the method as well as mechanisms that contribute to its effectiveness for circuit analysis are provided as these pathogens have been most widely applied in transneuronal tracing studies.
Untangling Neural Networks with Dual Retrograde Transsynaptic Viral Infection
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The ability of the recombinant RV to visualize the morphology of the infected cell and to infect primates in addition to rodents will make this technique a potential tool to provide new insights into the complex organization of brain networks.
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Biology, Medicine
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Biology, Medicine
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