The role of IL‐33 and its receptor ST2 in human nasal epithelium with allergic rhinitis

@article{Kamekura2012TheRO,
  title={The role of IL‐33 and its receptor ST2 in human nasal epithelium with allergic rhinitis},
  author={Ryuta Kamekura and Takashi Kojima and Ken-ichi Takano and Mitsuru Go and Norimasa Sawada and Tetsuo Himi},
  journal={Clinical \& Experimental Allergy},
  year={2012},
  volume={42},
  url={https://api.semanticscholar.org/CorpusID:21799632}
}
The IL‐33 induces T helper 2‐type inflammatory responses and is considered to play a crucial rule in allergic inflammations, such as asthma and atopic dermatitis, but the role of IL‐ 33 and its receptor ST2 in allergic rhinitis remains unknown.
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133 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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Results Citations
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133 Citations

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The IL-33/ST2 axis: Role in health and disease.

...

41 References

Association of serum interleukin‐33 level and the interleukin‐33 genetic variant with Japanese cedar pollinosis

Serum levels of IL‐33 and the genetic influences of the polymorphisms ofIL‐33 in human allergic diseases are unclear and type 2 T helper responses are studied.

Disease-associated functions of IL-33: the new kid in the IL-1 family

IL-33 is host-protective against helminth infection and reduces atherosclerosis by promoting TH2-type immune responses but can also promote the pathogenesis of asthma by expanding TH2 cells and mediate joint inflammation, atopic dermatitis and anaphylaxis by mast cell activation.

Characterization of the novel ST2/IL‐33 system in patients with inflammatory bowel disease

The novel association between the ST2/IL‐33 system and IBD seems to identify that variations in this axis might regulate the inflammatory process in these diseases.

IL-33 and IL-33 receptors in host defense and diseases.

The current knowledge regarding the roles of IL-33 andIL-33 receptors in host defense and disease development is summarized and discussed.

Cutting Edge: The ST2 Ligand IL-33 Potently Activates and Drives Maturation of Human Mast Cells1

It is reported that IL-33 directly stimulates primary human mast cells to produce several proinflammatory cytokines and chemokines and also exerts a permissive effect on the MCs response to thymic stromal lymphopoietin, a recently described potent MCs activator.

Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33.

It is demonstrated that basophils and eosinophils are the only direct target leukocytes for IL- 33, suggesting that IL-33 promotes allergic inflammation and Th2 polarization mainly by the selective activation of these specialized cells of the innate immune system.

A novel IL-1 family cytokine, IL-33, potently activates human eosinophils.

An IL-1 Cytokine Member, IL-33, Induces Human Basophil Activation via Its ST2 Receptor1

It is revealed that IL-33 potently regulates migration and activation of human basophils.

Interleukin‐33: a novel mediator with a role in distinct disease pathologies

IL‐33 – a novel mediator with a role in distinct disease pathologies (Key Symposium) and its role in immunity and inflammation is investigated.

IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation1

It is demonstrated here that IL-33/ST2 plays a significant role in the amplification of AAM polarization and chemokine production which contribute to innate and Ag-induced airway inflammation.