Chronic methamphetamine interacts with BDNF Val66Met to remodel psychosis pathways in the mesocorticolimbic proteome

@article{Greening2019ChronicMI,
  title={Chronic methamphetamine interacts with BDNF Val66Met to remodel psychosis pathways in the mesocorticolimbic proteome},
  author={David W. Greening and Michael J. Notaras and Maoshan Chen and Rong Xu and Joel D. Smith and Lesley Cheng and Richard J. Simpson and Andrew F. Hill and Maarten van den Buuse},
  journal={Molecular Psychiatry},
  year={2019},
  volume={26},
  pages={4431-4447},
  url={https://api.semanticscholar.org/CorpusID:209169489}
}
It is revealed that long-term Meth-induced brain changes are strongly dependent upon BDNF genetic variation, illustrating how drug-induced psychosis may be modulated at the molecular level by a single genetic locus.
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ncbi.nlm.nih.gov
38 Citations
Background Citations
11
Methods Citations
9

38 Citations

Enhanced methamphetamine sensitisation in a rat model of the brain-derived neurotrophic factor Val66Met variant: Sex differences and dopamine receptor gene expression

Modeling methamphetamine use disorder and relapse in animals: Short- and long-term epigenetic, transcriptional., and biochemical consequences in the rat brain

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Results show limited long-term effects of chronic Meth on a range of cognitive, affective and social behaviours despite marked drug-induced locomotor sensitization in mice.

Analysis of Acute and Chronic Methamphetamine Treatment in Mice on Gdnf System Expression Reveals a Potential Mechanism of Schizophrenia Susceptibility

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A previously unrecognised Notch1-Hes1-GABAB1 receptor-dependent mechanism involved in regulating mPFC neuronal activity and behavioural phenotypes in MIP is uncovered and provides mechanistic insight into the aetiology and pathophysiology of MIP.

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