SOX3 is required during the formation of the hypothalamo-pituitary axis

@article{Rizzoti2004SOX3IR,
  title={SOX3 is required during the formation of the hypothalamo-pituitary axis},
  author={Karine Rizzoti and Silvia Brunelli and Danielle F Carmignac and Paul Q. Thomas and Iain C.A.F. Robinson and Robin Lovell-Badge},
  journal={Nature Genetics},
  year={2004},
  volume={36},
  pages={247-255},
  url={https://api.semanticscholar.org/CorpusID:20696074}
}
How sensitive the pituitary is to subtle developmental defects is shown and how one gene can act at several levels in the hypothalamic-pituitary axis is shown.
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291 Citations

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42 References

Sox3 Is Required for Gonadal Function, but Not Sex Determination, in Males and Females

It is concluded that Sox3 is not required for gonadal determination but is important for normal oocyte development and male testis differentiation and gametogenesis and targeted mutagenesis to delete Sox3 from mice.

Sox 3 Is Required for Gonadal Function , but Not Sex Determination , in Males and Females

It is concluded that Sox3 is not required for gonadal determination but is important for normal oocyte development and male testis differentiation and gametogenesis and targeted mutagenesis to delete Sox3 from mice.

Multistep signaling requirements for pituitary organogenesis in vivo.

The molecular basis of generating diverse pituitary cell phenotypes from a common precursor is investigated, providing in vivo and in vitro evidence that their development involves three sequential phases of signaling events and the action of a gradient at an ectodermal boundary.

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The pituitary cells that produce TSH beta-subunit exhibited dramatic hypertrophy and hyperplasia as a result of the lack of thyroid function, consistent with a derivation of these three cell types from a common precursor.

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An important role for Hesx1/HESX1 in forebrain, midline and pituitary development in mouse and human is suggested.

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2.

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