Gonadal dysfunction and fertility problems in cancer survivors

@article{Brydy2007GonadalDA,
  title={Gonadal dysfunction and fertility problems in cancer survivors},
  author={Marianne Bryd{\o}y and Sophie D. Foss{\aa} and Olav Dahl and Trine Bj{\o}ro},
  journal={Acta Oncologica},
  year={2007},
  volume={46},
  pages={480 - 489},
  url={https://api.semanticscholar.org/CorpusID:20672988}
}
This review focuses on these problems in the young cancer survivors, where methods of protecting or restoring endocrine function and fertility need to be considered, and available methods for gonadal preservation should maximally be utilised.
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144 Citations
Highly Influential Citations
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Background Citations
36
Methods Citations
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Results Citations
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144 Citations

Anticancer treatment and fertility: Effect of therapeutic modalities on reproductive system and functions.

Preservation of female fertility during cancer treatment

A medical approach using the gonadotropin-releasing hormone analog (GnRHa) may act to protect the gonads during radiation and/or chemotherapy by preferentially steering cells into cell cycle arrest with a decline in responsibility to the chemotherapeutic agents.

Fertility Preservation in Gynecological Cancers

It is advocated that attention to long term health and quality of life in gonadotoxic therapy must be incorporated into plans as early as possible.

Fertility Preservation Options for Cancer Patients

Different options currently available to preserve fertility in men, women and adolescent children diagnosed with cancer and undergoing gonadotoxic therapy are presented.

Ovarian Function in Female Survivors of Childhood Malignancies

Female survivors of childhood malignancies had reduced ovarian reserve and reduced mean ovarian volume, especially those with older age, older age of menarche, and longer treatment duration.

Fertility considerations and preservation in haemato‐oncology patients undergoing treatment

The improved survival rates among patients with haematological malignancies, such as lymphoma and leukaemia, are shifting areas of focus towards understanding and preventing treatment‐induced sequelae, especially as pre‐pubertal patients present a unique constellation of fertility considerations.

Hypogonadism and Sexual Dysfunction in Testicular Tumor Survivors: A Systematic Review

The aim of this review was to summarize the current evidence on hypogonadism and sexual dysfunction in long-term cancer survivors, including the epidemiology of cardiovascular and metabolic disorders, to increase the awareness that serum testosterone levels, sexual function, and general health should be evaluated during the endocrinological management of these patients.

Fertility and Cancer

Hypogonadism After Childhood Cancer Treatment

In a study of 2283 long-term survivors of childhood cancer Byrne and colleagues found that RT below the diaphragm depressed fertility in both sexes for about 25%, ChT with alkylating agents (AA) with or without RT belowThe diaphagm depressed infertility in men, in women, however, AA therapy administered alone had no apparent effect on fertility.

Cancer and fertility: strategies to preserve fertility.

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75 References

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In addition to the many scientific and technical issues to be overcome prior to clinical application of these techniques, a number of ethical and legal issues must also be addressed to ensure a safe and realistic prospect for future fertility in these patients.

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In male cancer patients, surgery, radiotherapy and chemotherapy can be followed by transient or permanent infertility by affecting ejaculatory or erectile function, or by impairing spermatogenesis, and fertility-preserving measures before and during treatment should be considered.

Radiation damage to the uterus — Review of the effects of treatment of childhood cancer

It has been demonstrated that, in women treated with total body irradiation, sex steroid replacement in physiological doses significantly increases uterine volume and endometrial thickness, as well as re-establishing uterine blood flow, however, it is not known whether standard regimens of oestrogen replacement therapy are sufficient to facilitate uterine growth in adolescent women treated in childhood.

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The present study provides reassurance that cancer treatment using older protocols does not carry a large risk for genetic disease in offspring conceived many years after treatment, and cannot rule out the possibility that new therapeutic agents or specific combinations of agents at high doses may damage germ cells.
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