Tripartite synapses: astrocytes process and control synaptic information

@article{Perea2009TripartiteSA,
  title={Tripartite synapses: astrocytes process and control synaptic information},
  author={Gertrudis Perea and Marta Navarrete and Alfonso Araque},
  journal={Trends in Neurosciences},
  year={2009},
  volume={32},
  pages={421-431},
  url={https://api.semanticscholar.org/CorpusID:16355401}
}

Figures and Tables from this paper

Gliotransmission at Tripartite Synapses

The ability of astrocytes to release different gliotransmitters and modulate synaptic activity deepens the knowledge of the brain physiology.

Glial cells in neuronal network function

Current evidence that supports the notion that astrocytes are integral components of nervous system networks are summarized and some functional properties of intercellular signalling in neuron–glia networks are discussed.

Regulation of Multidirectional Communication within Tripartite Synapses in the Hippocampus

A contribution of postsynaptic neurons via K+ in shaping tripartite synaptic communication using astrocytic recordings to monitor extracellular potassium changes in hippocampal slices is demonstrated.

Communication Theoretical Modeling and Analysis of Tripartite Synapses With Astrocytes in Synaptic Molecular Communication

The combined effect of short-term depression (STD) and long-term potentiation (LTP) on vesicle release process in a tripartite synapse is studied and the effect of different synaptic parameters such as number of releasable vesicles, input spike rate and replenishment rate, is analyzed on information transmission.

ASTROCYTE-MEDIATED SHORT-TERM SYNAPTIC DEPRESSION

It is found that the PBD develops over the first three postnatal weeks and that it is blocked when astrocyte metabolism is compromised, suggesting thatAstrocytes are critically involved in mediating a negative feedback on synaptic transmission after a burst of synaptic activity.

Microglia regulate synaptic development and plasticity

This review will broadly introduce studies that report the roles of microglia in synaptic plasticity and the possible underlying molecular mechanisms.
...

The tripartite synapse: glia in synaptic transmission

The concept of glial cells as active elements of the synapse and the nervous circuitry is introduced, the experimental evidence supporting this is described and a revised view of brain activity based on this integrated network of interactive neurons and glia is suggested.

Glial modulation of synaptic transmission in culture

Evidence showing the ability of astrocytes to modulate synaptic transmission directly is reviewed, with the focus on studies performed on cell culture preparations, which have been proved extremely useful in the characterization of molecular and cellular processes involved in astroCyte‐mediated neuromodulation.

Synaptic information processing by astrocytes

Glutamate exocytosis from astrocytes controls synaptic strength

It is shown that glutamate exocytosis from astrocytes of the rat hippocampal dentate molecular layer enhances synaptic strength at excitatory synapses between perforant path afferents and granule cells.

Cooperative Astrocyte and Dendritic Spine Dynamics at Hippocampal Excitatory Synapses

This work presents a system that can be used to characterize the intricate relationship between astrocytic processes and synaptic structures in situ using organotypic hippocampal slices, a preparation that retains the three-dimensional architecture ofAstrocyte–synapse interactions.

Glial modulation of synaptic transmission in the hippocampus

Evidence of bidirectional communication between astrocytes and neurons emerging from recent studies using acute slice preparations is summed up.
...