Planning of randomized early detection trials

@article{Hu2004PlanningOR,
  title={Planning of randomized early detection trials},
  author={Ping Hu and Marvin Zelen},
  journal={Statistical Methods in Medical Research},
  year={2004},
  volume={13},
  pages={491 - 506},
  url={https://api.semanticscholar.org/CorpusID:12838050}
}
Consider a randomized clinical trial to evaluate the benefit of screening an asymptomatic population and two designs are discussed, for example the ‘up-front design’ in which all subjects receive an initial exam and then are randomized to the usual care and study groups and the “close-out design” in which the usual Care group receives an exam which is timed to be given at the same time as the last exam in the study group.
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