Evolution and Diversification of the Nuclear Receptor Superfamily a

@article{Escriv1998EvolutionAD,
  title={Evolution and Diversification of the Nuclear Receptor Superfamily a},
  author={H{\'e}ctor Escriv{\'a} and Marie‐Claire Langlois and RICARDO LUIS Mendonça and Ray Pierce and Vincent Laudet},
  journal={Annals of the New York Academy of Sciences},
  year={1998},
  volume={839},
  url={https://api.semanticscholar.org/CorpusID:11164838}
}
A new molecular phylogeny of the nuclear receptor superfamily is presented and the validity of this phylogenetic model is tested by identifying homologs of known nuclear receptors in early metazoans.
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27 Citations
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27 Citations

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5 References

Evolution of the nuclear receptor gene superfamily.

A complex evolutionary history for nuclear receptor genes in which gene duplication events and swapping between domains of different origins took place is suggested.

The origin of nuclear receptor proteins: a single precursor distinct from other transcription factors.

Nuclear receptor proteins regulate transcription under the influence of hormones or other small ligands, and two evolutionary histories have bean proposed, which assume independent origins for the different domains.

Phylogeny of the steroid receptor superfamily.

Both PAUP and N-J evolutionary trees showed that the receptors within the subgroups of a major sublineage tend to recognize hormones of very similar structure, which suggests that the relative phylogenetic position of orphans to well-characterized receptors might be exploited to predict the type of ligand they would recognize.

Gene duplications and the origins of vertebrate development.

From amphioxus and vertebrate homeobox gene expression patterns, it is suggested that there are multiple routes by which new genes arising from gene duplication acquire new functions and permit the evolution of developmental innovations.

Transcription factors 3: nuclear receptors.